Genes that are transcriptionally regulated by HIF1A [GeneID=3091].
| PAG Title | Genes that are transcriptionally regulated by HIF1A [GeneID=3091]. |
| PAG ID | MAX002602 |
| Type | A |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability. The HIF-1beta subunit is constitutively expressed, whereas the HIF-1alpha subunit is subject to ubiquitination and proteasomal degradation, a process that is inhibited under hypoxic conditions. Recent data indicate that HIF-1 plays major roles in the prevention of myocardial and cerebral ischemia and in the pathogenesis of pulmonary hypertension and cancer. Modulation of HIF-1 activity by genetic or pharmacological means could provide a novel therapeutic approach to these common causes of mortality. |
| Species | Homo sapiens |
| nCoCo Score | 530 |
| Base PAG ID | MAX002602 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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